Sensory Neuronopathy and Autoimmune Diseases

Sensory Neuronopathy and Autoimmune Diseases

Sensory neuronopathies (SNs) are a specific subgroup of peripheral nervous system diseases characterized by primary degeneration of dorsal root ganglia and their projections. Multifocal sensory symptoms often associated to ataxia are the classical features of SN. Several different etiologies have been described for SNs, but immune-mediated damage plays a key role in most cases. SN may herald th...

Sjögren Sensory Neuronopathy (Sjögren Ganglionopathy)

Primary Sjögren syndrome (SS) is an autoimmune disease mainly affecting the exocrine glands causing a sicca syndrome. Neurological manifestations are rarely seen in SS although they are debilitating. Peripheral neuropathies namely sensory axonal neuropathy and painful small fiber neuropathy are the most frequent neurological manifestations. Sensory neuronopathy (SN) is less frequently seen alth...

Slowly progressive sensory hemisyndrome: unusual presentation of paraneoplastic sensory neuronopathy.

Dear Editor, A 59-year-old woman complained of slowly progressive unsteadiness, gait difficulties, and a left sensory hemisyndrome. She had smoked heavily until 2004. In October 2006, she complained of diffuse muscle pain and fever, and a chest computed tomography (CT) scan was normal. Four months later, right pulmonary arterial thromboembolism was diagnosed at repeat CT scan. Symptoms disappea...

Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy.

An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of proces...

Air Pollution and its Effects on Autoimmune Diseases